期刊
ANNALS OF SURGICAL ONCOLOGY
卷 28, 期 4, 页码 2182-2190出版社
SPRINGER
DOI: 10.1245/s10434-020-09152-8
关键词
-
资金
- UNC Oncology K12 [K12CA120780]
Inflammatory breast cancer has historically been associated with high recurrence rates and poor survival, but advancements in systemic therapy have improved outcomes. This study found that positive lymph nodes post-NAC varied by subtype and clinical nodal status, providing meaningful prognostic information in all subtypes. Further research is needed to identify less invasive methods of axillary staging in IBC patients.
Background Inflammatory breast cancer (IBC) has historically been characterized by high rates of recurrence and poor survival; however, there have been significant improvements in systemic therapy. We sought to investigate modern treatment of IBC and define the yield and prognostic significance of axillary lymph nodes after neoadjuvant chemotherapy (NAC). Methods Women with clinical stage T4d, N0-N3, M0 IBC from 2012 to 2016 in the National Cancer Database were included. Kaplan-Meier survival curves and Cox regression were used to assess mortality by receptor subtype and nodal status. Results We identified 5265 patients; 37% hormone receptor (HR) +/HER2 - , 19% HR +/HER2 + , 18% HR -/HER2 + , and 26% triple-negative, and 5-year overall survival was 51.6%. Only 34% were treated according to guidelines with NAC, modified radical mastectomy, and adjuvant radiation. Pathologically positive lymph nodes (ypN +) after NAC varied by subtype and clinical nodal status (cN) ranging from 82% in cN + HR +/HER2 - patients to 19% in cN0 HR -/HER2 + patients. ypN + strongly correlated with survival in all subtypes with the most pronounced impact in HR +/HER2 + patients, with 90% 5-year overall survival in ypN0 versus 66% for ypN + (HR 4.29, 95% CI 1.58-11.70,p = 0.03). Conclusions Five-year survival in M0 IBC is 51.6%. Positive nodes after NAC varied by subtype and clinicalNstatus but is sufficiently high and provided meaningful prognostication in all subtypes to support continued routine pathologic assessment. Future study is warranted to identify reliable, less morbid, methods of staging the axilla in IBC patients appropriate for deescalation of axillary surgery.
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