A Yorkshire swine (Sus scrofa domesticus) model for nerve regeneration and ischemia based on the sciatic nerve and femoral C artery

Animal studies are essential to biomedical research and the cornerstone is a reproducible animal model. While there are many reports on rodent peripheral nerve injury models, a large animal model is essential to confirm the effects of nerve regeneration over the longer distances of regeneration required in humans. Swine have long been used as a large animal model for other surgical and biomedical studies. This paper represents a novel neurovascular injury model in the Sus scrofa domesticus swine (American Yorkshire pig). This paper will describe our experience and recommendations with pre-operative, operative and post-operative protocols and our refinements to produce an effective model. (C) 2020 Elsevier GmbH. All rights reserved.

Automated summary

Animal studies are crucial in biomedical research, with large animal models essential for confirming nerve regeneration effects over longer distances required in humans. This paper presents a novel neurovascular injury model in the Sus scrofa domesticus swine, describing the authors' experience and recommendations for creating an effective model.