期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 52, 页码 23598-23602出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202009395
关键词
BINAMs; kinetic resolution; NOBINs; organocatalysis; protecting-group-free
资金
- NSFC [21702138]
- ShanghaiTech University
- Analytical Instrumentation Center, SPST, ShanghaiTech University [SPST-AIC10112914]
A versatile kinetic resolution of protecting-group-free BINAMs and NOBINs has been realized through chiral phosphoric acid catalyzed triazane formation with azodicarboxylates. A series of mono-N-protected and unprotected BINAMs, diphenyl diamines and NOBIN derivatives could be kinetically resolved with excellent performances (with s factor up to 420). The gram-scale reactions and facile derivatizations of the chiral products demonstrate the potential of these methods in the asymmetric synthesis of chiral catalysts and ligands.
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