期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 52, 页码 23527-23531出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202010021
关键词
[5]helicenes; asymmetric catalysis; cationic phosphonites; gold catalysis; ligand design
资金
- Deutsche Forschungsgemeinschaft [Al 11348/4-3, INST 186/1237-1, INST 186/1298-1]
The synthesis of unprecedented BINOL-derived cationic phosphonites is described. Through the use of these phosphanes as ancillary ligands in Au(I)catalysis, a highly regio- and enantioselective assembly of appropriately designed alkynes into 1-(aryl)benzo[5]carbohelicenes is achieved. The modular synthesis of these ligands and the enhanced reactivity that they impart to Au-I-centers after coordination have been found to be the key features that allow an optimization of the reaction conditions until the desired benzo[5]helicenes are obtained with high yield and enantioselectivity.
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