期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 4, 页码 2130-2134出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202009323
关键词
alkyl bromides; asymmetric C− H functionalization; azoles; copper catalysis; enantioselectivity
资金
- [NSFC-21772218]
- [21821002]
- [XDB20000000]
A catalytic asymmetric alkylation of azoles with secondary 1-arylalkyl bromides through direct C-H functionalization was reported. The reaction, under blue-light photoexcitation, showed good reactivity and high stereoselectivity, providing an efficient strategy for the construction of chiral alkyl azoles at low temperature. The reactions are compatible with a wide range of azoles.
A catalytic asymmetric alkylation of azoles with secondary 1-arylalkyl bromides through direct C-H functionalization is reported. Under blue-light photoexcitation, a copper(I)/carbazole-based bisoxazoline (CbzBox) catalytic system exhibits good reactivity and high stereoselectivity, thus offering an efficient strategy for the construction of chiral alkyl azoles. These reactions proceed at low temperature and are compatible with a wide range of azoles.
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