4.8 Article

Light-Promoted Copper-Catalyzed Enantioselective Alkylation of Azoles

期刊

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 4, 页码 2130-2134

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202009323

关键词

alkyl bromides; asymmetric C− H functionalization; azoles; copper catalysis; enantioselectivity

资金

  1. [NSFC-21772218]
  2. [21821002]
  3. [XDB20000000]

向作者/读者索取更多资源

A catalytic asymmetric alkylation of azoles with secondary 1-arylalkyl bromides through direct C-H functionalization was reported. The reaction, under blue-light photoexcitation, showed good reactivity and high stereoselectivity, providing an efficient strategy for the construction of chiral alkyl azoles at low temperature. The reactions are compatible with a wide range of azoles.
A catalytic asymmetric alkylation of azoles with secondary 1-arylalkyl bromides through direct C-H functionalization is reported. Under blue-light photoexcitation, a copper(I)/carbazole-based bisoxazoline (CbzBox) catalytic system exhibits good reactivity and high stereoselectivity, thus offering an efficient strategy for the construction of chiral alkyl azoles. These reactions proceed at low temperature and are compatible with a wide range of azoles.

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