期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 44, 页码 19610-19617出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202006861
关键词
adjuvants; aluminum; coordination chemistry; mesoporous materials; surface chemistry
Aluminum-containing adjuvants used in vaccine formulations suffer from low cellular immunity, severe aggregation, and accumulation in the brain. Conventional aluminosilicates widely used in the chemical industry focus mainly on acidic sites for catalytic applications, but they are rarely used as adjuvants. Reported here is an innovative ligand-assisted steric hindrance strategy to create a high density of six-coordinate(VI)Al-OH groups with basicity on dendritic mesoporous silica nanoparticles as new nanoadjuvants. Compared to four-coordinate(IV)Al-modified counterparts,Al-VI-OH-rich aluminosilicate nanoadjuvants enhance cellular delivery of antigens and provoke stronger cellular immunity. Moreover, the aluminum accumulation in the brain is more reduced than that with a commercial adjuvant. These results show that coordination chemistry can be used to control the adjuvanticity, providing new understanding in the development of next-generation vaccine adjuvants.
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