期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 52, 页码 23690-23696出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202008681
关键词
adhesion; cancer; extracellular matrix; sialic acid; tumorigenesis
资金
- DBT [BT/PR26526/GET/119/92/2017]
- DST-SERB
- IISc
- Ministry of Human Resource Development (MHRD), Government of India
- Wellcome Trust/DBT India Alliance Fellowship/Grant [IA/I/17/2/503312]
- DBT-IISc partnership program [BT/PR27952/INF/22/212/2018]
- MHRD
- MeitY
- IISc Biosciences
The invasion of cancer is brought about by continuous interaction of malignant cells with their surrounding tissue microenvironment. Investigating the remodeling of local extracellular matrix (ECM) by invading cells can thus provide fundamental insights into the dynamics of cancer progression. In this paper, we use an active untethered nanomechanical tool, realized as magnetically driven nanomotors, to locally probe a 3D tissue culture environment. We observed that nanomotors preferentially adhere to the cancer-proximal ECM and magnitude of the adhesive force increased with cell lines of higher metastatic ability. We experimentally confirmed that sialic acid linkage specific to cancer-secreted ECM makes it differently charged, which causes this adhesion. In an assay consisting of both cancerous and non-cancerous epithelia, that mimics the in vivo histopathological milieu of a malignant breast tumor, we find that nanomotors preferentially decorate the region around the cancer cells.
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