期刊
ANALYTICAL CHEMISTRY
卷 92, 期 19, 页码 13017-13024出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.0c01857
关键词
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资金
- Business Finland [FEDOC 211637, FEPOD 2117731]
- Aalto CHEM Doctoral School
- Orion Research Foundation Sr
A disposable electrochemical test strip for the quantitative point-of-care (POC) determination of acetaminophen (paracetamol) in plasma and finger-prick whole blood was fabricated. The industrially scalable dry transfer process of single-walled carbon nanotubes (SWCNTs) and screen printing of silver were combined to produce integrated electrochemical test strips. Nafion coating stabilized the potential of the Ag reference electrode and enabled the selective detection in spiked plasma as well as in whole blood samples. The test strips were able to detect acetaminophen in small 40 mu L samples with a detection limit of 0.8 mu M and a wide linear range from 1 mu M to 2 mM, well within the required clinical range. After a simple 1:1 dilution of plasma and whole blood, a quantitative detection with good recoveries of 79% in plasma and 74% in whole blood was achieved. These results strongly indicate that these electrodes can be used directly to determine the unbound acetaminophen fraction without the need for any additional steps. The developed test strip shows promise as a rapid and simple POC quantitative acetaminophen assay.
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