期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 412, 期 27, 页码 7659-7667出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-020-02903-2
关键词
Surface-enhanced Raman spectroscopy (SERS); SERS substrates; Biomarkers; LGAL3BP; Bioanalytical methods
资金
- Universita degli Studi Roma Tre within the CRUI-CARE Agreement
- LazioInnova, ADVISER (Automatic DeVIce for Smart dEtection of tumouRs) project, POR FESR Lazio 2014-2020 [CUP F85F18000070007]
- National Funding for Centers of Excellence (Science Department, Roma Tre University - MIUR) [Articolo 1, Commi 314-337 Legge 232/2016]
The research and the individuation of tumour markers in biological fluids are currently one of the main tools to support diagnosis, prognosis, and monitoring of the therapeutic response in oncology. Although the identification of tumour markers in asymptomatic patients is crucial for early diagnosis, its application is still limited by the relatively low sensitivity and the complexity of existing methods (i.e. ELISA, mass spectrometry). We developed an easy, fast, and ultrasensitive surface-enhanced Raman scattering (SERS)-based system, for the detection and quantitation of the LGALS3BP (90K) biomarker that was used as a model, based on the development of antibody-functionalized nanostructured gold surfaces. The detection system was effective for the ultrasensitive detection and characterization of samples of different biochemical compositions. In conclusion, this work could provide the foundation for the development of a medical diagnostic device with the highest predictive power when compared with the methods currently used in cancer diagnostics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据