期刊
ANALYTICA CHIMICA ACTA
卷 1146, 期 -, 页码 184-199出版社
ELSEVIER
DOI: 10.1016/j.aca.2020.10.009
关键词
Point-of-care; COVID-19; Influenza; Ebola; Pandemic; Lab-on-a-chip
资金
- National Science Foundation Graduate Research Fellowship
The COVID-19 pandemic highlighted the lack of diagnostic solutions that can keep up with the rapid spread of the virus. The review assesses the progress of point-of-care technologies for diagnosing viral diseases that cause pandemics, focusing on design requirements, assay technologies, and sample preparation challenges. Recommendations are provided for specific challenges to address in preparation for future pandemics.
The COVID-19 global pandemic of 2019-2020 pointedly revealed the lack of diagnostic solutions that are able to keep pace with the rapid spread of the virus. Despite the promise of decades of lab-on-a-chip research, no commercial products were available to deliver rapid results or enable testing in the field at the onset of the pandemic. In this critical review, we assess the current state of progress on the development of point-of-care technologies for the diagnosis of viral diseases that cause pandemics. While many previous reviews have reported on progress in various lab-on-a-chip technologies, here we address the literature from the perspective of the testing needs of a rapidly expanding pandemic. First, we recommend a set of requirements to heed when designing point-of-care diagnostic technologies to address the testing needs of a pandemic. We then review the current state of assay technologies with a focus on isothermal amplification and lateral-flow immunoassays. Though there is much progress on assay development, we argue that the largest roadblock to deployment exists in sample preparation. We summarize current approaches to automate sample preparation and discuss both the progress and shortcomings of these developments. Finally, we provide our recommendations to the field of specific challenges to address in order to prepare for the next pandemic. (C) 2020 Elsevier B.V. All rights reserved.
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