期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 21, 期 1, 页码 103-113出版社
WILEY
DOI: 10.1111/ajt.16268
关键词
-
资金
- Agency for Healthcare Research and Quality [R18 HS020610]
- National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [R01-DK093513]
This study simulates a revised kidney allocation system and estimates the potential increase in number of transplants by including deceased donor kidneys as chain-initiating kidneys in a kidney paired donation pool. The simulations show that this approach can significantly increase the number of transplants and reduce the waiting times for KPDP candidates.
As proof of concept, we simulate a revised kidney allocation system that includes deceased donor (DD) kidneys as chain-initiating kidneys (DD-CIK) in a kidney paired donation pool (KPDP), and estimate potential increases in number of transplants. We consider chains of length 2 in which the DD-CIK gives to a candidate in the KPDP, and that candidate's incompatible donor donates to theDD waitlist. In simulations, we vary initial pool size, arrival rates of candidate/donor pairs and (living) nondirected donors (NDDs), and delay time from entry to the KPDP until a candidate is eligible to receive a DD-CIK. Using data on candidate/donor pairs and NDDs from the Alliance for Paired Kidney Donation, and the actual DDs from the Scientific Registry of Transplant Recipients (SRTR) data, simulations extend over 2 years. With an initial pool of 400, respective candidate and NDD arrival rates of 2 per day and 3 per month, and delay times for access to DD-CIK of 6 months or less, including DD-CIKs increases the number of transplants by at least 447 over 2 years, and greatly reduces waiting times of KPDP candidates. Potential effects on waitlist candidates are discussed as are policy and ethical issues.
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