期刊
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
卷 64, 期 1, 页码 19-28出版社
AMER THORACIC SOC
DOI: 10.1165/rcmb.2020-0196TR
关键词
acute lung injury; gut-lung axis; inflammation; mesenteric lymph; permeability
资金
- U.S. National Institutes of Health [GM097270, HL150732, HL120954]
- Department of Veterans Affairs [IK6BX004210]
The study summarizes the role of mesenteric lymph in injury or infection, revealing its impact on lung injury and systemic inflammation. Additionally, potential injurious factors and anti-inflammatory factors in the lymph, as well as the bidirectional nature of the gut-lung axis in inflammation, were discussed.
Emerging evidence shows that after injury or infection, the mesenteric lymph acts as a conduit for gut-derived toxic factors to enter the blood circulation, causing systemic inflammation and acute lung injury. Neither the cellular and molecular identity of lymph factors nor their mechanisms of action have been well understood and thus have become a timely topic of investigation. This review will first provide a summary of background knowledge on gut barrier and mesenteric lymphatics, followed by a discussion focusing on the current understanding of potential injurious factors in the lymph and their mechanistic contributions to lung injury. We also examine lymph factors with antiinflammatory properties as well as the bidirectional nature of the gut-lung axis in inflammation.
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