The Impact of Race on Short-term Treatment Response to Bevacizumab in Diabetic Macular Edema

PURPOSE: To determine the impact of race and ethnicity on efficacy of intravitreal bevacizumab for diabetic macular edema in anti-vascular endothelial growth factor (VEGF) treatment-naive patients. DESIGN: Retrospective cohort study. METHODS: SETTING: Urban-based academic institution with affiliated private offices. STUDY POPULATION: Intravitreal anti-VEGF naive patients seen between 2010 and 2019 of White (W) race, Black (B) race, or Hispanic (H) ethnicity aged 18 years and older with diabetic macular edema who received intravitreal injections of bevacizumab. Exclusion criteria were prior intravitreal antiVEGF treatment, invasive ophthalmologic interventions, and laser treatments within 3 months prior to first injection through the duration of the study. EXPOSURES: Intravitreal bevacizumab. MAIN OUTCOMES MEASURES: Percentage of patients with visual acuity (VA) improvement and mean percentage reduction in central macular thickness (CMT). RESULTS: Percentage with VA improvement was 27% vs 39% vs 50% after 1 injection (n = 314), and 34% vs 55% vs 59% after 3 injections (n = 150) for B, H, andW cohorts, respectively. Black patients experienced lower odds of VA improvement compared withWhite and Hispanic patients after 1 injection (odds of 0.480, CI 0.284-0.814, P = .006) and 3 injections (odds of 0.342, CI 0.149-0.782, P = .008) while controlling for age, sex, baseline glycated hemoglobin (HbA1c), baseline CMT, baseline VA, laser history, injection time course, and follow-up delay. CONCLUSIONS: Black patients had a significantly lower likelihood of visual acuity improvement following intravitreal bevacizumab treatment compared with White and Hispanic patients. Further research is warranted to understand the effect of race and ethnicity on anti-VEGF efficacy to ensure optimal treatment for each individual. (C) 2020 Elsevier Inc. All rights reserved.

Automated summary

This study aimed to investigate the impact of race and ethnicity on the efficacy of anti-VEGF treatment for diabetic macular edema. The results showed that black patients had significantly lower odds of visual acuity improvement following intravitreal bevacizumab treatment compared to white and Hispanic patients. Further research is needed to understand the effects of race and ethnicity on anti-VEGF efficacy for optimal individual treatment.