期刊
ALZHEIMERS & DEMENTIA
卷 16, 期 12, 页码 1704-1713出版社
WILEY
DOI: 10.1002/alz.12170
关键词
Alzheimer's disease; bilingualism; cognitive reserve; dementia; multilingualism; primary progressive aphasia
资金
- National Institutes of Health [NINDSR01 NS050915, NIDCD K24DC015544, NIDCDR01 DC016291, NIA P50AG023501, NIA P01AG019724, NIDCD F31DC016229, NIDCDK23DC018021]
Introduction: The effect of bilingualism on age at onset has yet to be examined within different clinical variants of Alzheimer's disease. Methods: We reviewed the research charts of 287 well-characterized participants with either amnestic Alzheimer's dementia or logopenic variant primary progressive aphasia (lvPPA) and identified bilingual speakers based on regular use of two or more languages and/or ability to communicate with native speakers in two or more languages. We evaluated whether bilingual speakers demonstrated a delay in age of symptom onset relative to monolingual speakers while controlling for other variables known to influence cognitive reserve. Results: A 5-year delay in age at symptom onset was observed for bilingual relative to monolingual speakers with lvPPA. This delay in onset was not observed in the amnestic Alzheimer's dementia cohort. Discussion: Bilingualism may serve as a unique cognitive reserve variable in lvPPA, but not in amnestic Alzheimer's dementia.
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