Visible-Light-Initiated Cascade Reaction of 2-Isothiocyanatonaphthalenes and Amines under Additive- and External Photocatalyst-Free and Mild Conditions

A simple and efficient visible-light-initiated cascade reaction of 2-isothiocyanatonaphthalenes and amines with ambient dioxygen as the sole oxidant under additive-, external photocatalyst-free and ambient conditions was developed. 38 Examples of N-substituted naphtho[2,1-d]thiazol-2-amines were regioselectively constructed in good to excellent yields.

Automated summary

A simple and efficient visible-light-initiated cascade reaction was developed for the regioselective construction of N-substituted naphtho[2,1-d]thiazol-2-amines in good to excellent yields. This reaction was carried out under additive-, external photocatalyst-free and ambient conditions, using ambient dioxygen as the sole oxidant.