期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 362, 期 23, 页码 5363-5367出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202000985
关键词
aryl halides; nickel; reductive coupling; radical reactions; C-C coupling
资金
- National Science Foundation of China [21971228, 21772187]
- China Postdoctoral Science Foundation [2019 M653580]
A nickel-catalyzed direct trifluoroethylation of aryl iodides with an industrial raw material CF3CH2I has been developed, demonstrating high efficiency, excellent functional-group compatibility, especially with large sterically hindered groups. The key to success is the combination of nickel with readily available nitrogen and phosphine ligands. The powerful potential of this strategy is further demonstrated by the late-stage modification of several derived bioactive molecules.
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