期刊
ADVANCED MATERIALS
卷 32, 期 51, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202002440
关键词
cancer therapeutics; characterization and clinical-grade exosomes; exosomes; extracellular vesicles; immunotherapy
类别
资金
- National Research Foundation of Korea (NRF) - Korean government (MSIT) [2017R1A3B1023418]
- KU-KIST School Project
- KIST Institutional Program
- National Research Foundation of Korea [2017R1A3B1023418] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Exosomes are a class of extracellular vesicles of around 100 nm in diameter that are secreted by most cells and contain various bioactive molecules reflecting their cellular origin and mediate intercellular communication. Studies of these exosomal features in tumor pathogenesis have led to the development of therapeutic and diagnostic approaches using exosomes for cancer therapy. Exosomes have many advantages for conveying therapeutic agents such as small interfering RNAs, microRNAs, membrane-associated proteins, and chemotherapeutic compounds; thus, they are considered a prime candidate as a delivery tool for cancer treatment. Since exosomes also provide an optimal microenvironment for the effective function of immunomodulatory factors, exosomes harboring bioactive molecules have been bioengineered as cancer immunotherapies that can effectively activate each stage of the cancer immunity cycle to successfully elicit cancer-specific immunity. This review discusses the advantages of exosomes for treating cancer and the challenges that must be overcome for their successful clinical development.
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