期刊
ADVANCED FUNCTIONAL MATERIALS
卷 31, 期 1, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202005792
关键词
hydrophobic drugs; microarray patches; microneedles; nanocrystals; poorly soluble drugs
Poorly soluble drugs make up a significant portion of the pharmaceutical market, with microarray patches (MAPs) showing potential as a strategy for delivering such drugs through the skin. The future of MAPs looks promising in terms of providing a convenient and effective therapeutic alternative for patients.
Poorly soluble drugs constitute more than 60% of currently marketed pharmaceuticals with over two-thirds of promising new chemical entities failing to enter a clinical setting due to solubility issues. Although oral formulations have made some impact, alternative enhancement strategies for administration of such molecules are actively sought. Over the last decade, innovation on a global scale has enabled the expansion of the frontiers of microarray patches (MAPs) further than ever before. Initially designed to load low doses of hydrophilic and potent therapeutic agents, MAPs are now becoming a viable strategy for the immediate and long-acting delivery of poorly soluble drugs through the skin. This together with the advantages of transdermal administration over the oral and parenteral routes, make of MAPs an appealing platform for the development of products with increased patient compliance. Undoubtedly, MAPs will soon become a readily available therapeutic alternative, and experts from academia, industry and regulatory bodies are working together aiming to facilitate the progression of MAPs toward safe and effective clinical use. This review aims to highlight the ability of MAPs to deliver poorly soluble actives, discuss the mechanisms behind in-skin drug absorption, and evaluate the future direction of the field.
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