期刊
ADVANCED FUNCTIONAL MATERIALS
卷 30, 期 49, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202002730
关键词
intratumoral thermal sensing; luminescence nanothermometry; photothermal therapies
类别
资金
- Ministerio de Economia y Competitividad-MINECO [MAT2016-75362-C3-1-R]
- Ministerio de Ciencia e Innovacion de Espana [PID2019-106211RB-I00]
- Comunidad de Madrid [B2017/BMD-3867 RENIM-CM]
- European Union [801305]
- project CICECO-Aveiro Institute of Materials - Portuguese Foundation for Science and Technology (FCT)/MCTES [UIDB/50011/2020, UIDP/50011/2020]
- China Scholarship Council (CSC) [201806870023]
- European Union's Horizon 2020 research and innovation programme under the Marie Skodowska Curie Grant [709270]
- Juan de la Cierva Formacion scholarship [FJC2018-036734-I]
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) [431736/2018-9, 304967/20181]
- FAPEAL (FundacAo de Amparo a Pesquisa do Estado de Alagoas) [1209/2016]
- CNPq
- sandwich doctoral program (PDSE-CAPES) [88881/2016-01]
- European Structural and Investment Fund
- Marie Curie Actions (MSCA) [709270] Funding Source: Marie Curie Actions (MSCA)
The emergence of luminescence nanothermometry in bio and nanomedicine has enabled achievements outside the reach of conventional techniques. For instance, it has provided real-time monitoring of in vivo thermal therapies of tumors, a mandatory requirement for these techniques to work safely and efficiently. However, the reliability of intratumoral thermal readings is currently in question due to the presence of artefacts caused by the inhomogeneous optical properties of biological tissues. This work demonstrates how it is possible to avoid, under specific conditions, these artefacts and reach precise and reliable in vivo intratumoral thermal feedback during in vivo photothermal treatments. The method proposed is based on the use of luminescent nanoparticles capable of multiparametric thermal sensing. The results demonstrate how the convergence of the different thermal readouts becomes a solid indicator of their reliability. It is shown how this new approach makes possible precise (thermal uncertainties below 1 degrees C) intratumoral thermal feed-back, while simple, efficient, and minimally invasive in vivo thermal treatments of surface tumors is carried out. Results included in this work provide an ingenious route toward the consolidation of luminescence nanothermometry as a convincing technique for high sensitivity preclinical thermal sensing, while also constituting a step toward improved photothermal therapies.
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