期刊
ADVANCED FUNCTIONAL MATERIALS
卷 30, 期 42, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202003710
关键词
3; 4-ethylenedioxythiophene; biomaterials; electrospinning; neurite outgrowth; tissue engineering
类别
资金
- EPSRC Centre for Doctoral Training in Neurotechnology
- Engineering and Physical Sciences Research Council [EP/L016737/1]
- Whitaker International Program fellowship
- Neuroforbundet
- Swedish Research Council [VR 2015-02904]
- European Union's Horizon 2020 Research and Innovation Programme through the Marie Skodowska-Curie Individual Fellowship RAISED [660757]
- UK Regenerative Medicine Platform A Hub for Engineering and Exploiting the Stem Cell Niche [MR/K026666/1]
- European Commission grant SAVVY [310445]
- Wellcome Trust Seed Award in Science [213949/Z/18/Z]
- MRC [MR/K026666/1] Funding Source: UKRI
- Swedish Research Council [2015-02904] Funding Source: Swedish Research Council
- Marie Curie Actions (MSCA) [660757] Funding Source: Marie Curie Actions (MSCA)
- Wellcome Trust [213949/Z/18/Z] Funding Source: Wellcome Trust
The unique electrochemical properties of the conductive polymer poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) make it an attractive material for use in neural tissue engineering applications. However, inadequate mechanical properties, and difficulties in processing and lack of biodegradability have hindered progress in this field. Here, the functionality of PEDOT:PSS for neural tissue engineering is improved by incorporating 3,4-ethylenedioxythiophene (EDOT) oligomers, synthesized using a novel end-capping strategy, into block co-polymers. By exploiting end-functionalized oligoEDOT constructs as macroinitiators for the polymerization of poly(caprolactone), a block co-polymer is produced that is electroactive, processable, and bio-compatible. By combining these properties, electroactive fibrous mats are produced for neuronal culture via solution electrospinning and melt electrospinning writing. Importantly, it is also shown that neurite length and branching of neural stem cells can be enhanced on the materials under electrical stimulation, demonstrating the promise of these scaffolds for neural tissue engineering.
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