期刊
ADVANCED FUNCTIONAL MATERIALS
卷 30, 期 52, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202006454
关键词
extracellular matrix; glycopeptide hydrogel; macrophage polarization; wound healing
类别
资金
- CAMS Innovation Fund for Medical Sciences [2017-I2M-4-001]
- National Natural Science Foundation of China [31670977, 31870950, 31971306]
- Young Elite Scientists Sponsorship Program by Tianjin [TJSQNTJ-2018-01]
- Tianjin Innovation and Promotion Plan Key Innovation Team of Immunoreactive Biomaterials
- Specific Program for High-Tech Leader & Team of Tianjin Government
- China Postdoctoral Science Foundation [2019M660029]
Wound management remains a major concern in clinical care. Conventional dressings and hydrogels delivering drugs or cells can drive wound healing. However, these approaches are limited either by unnecessary bleeding and tissue tearing, or sophisticated fabrication, high cost, and drug-related side effects. Herein, a novel bioinspired glycopeptide hydrogel is rationally designed to mimic the glycoprotein components and nanofibrous architecture of cutaneous extracellular matrix (ECM) for self-accelerating the wound healing by regulating macrophage polarization without any additional therapeutic agents. The glycopeptide hydrogel, termed as GM-peptide hybrid hydrogel (GP(gel)), is established by the self-assembly of beta-sheet Q11 peptide-grafted glucomannan, with nanofibrous structure, high water content, porosity, and self-healing properties. It is observed that GP(gel)displays remarkable capability of polarizing primary macrophages to M2-type phenotype in vitro and in vivo by inducing the activation of mannose receptors through ERK/STAT6 pathway. GP(gel)unprecedentedly expedites the wound closure rate and the regeneration of epidermis tissues in full-thickness skin excision models without drugs, exogenous cytokines, or seeded cells. More significantly, GP(gel)could promote angiogenesis in the repaired skin tissues. Collectively, such a novel ECM-mimicking glycopeptide hydrogel provides a highly effective treatment approach for skin wounds and may serve as a promising scaffold in regenerative medicine.
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