期刊
ADVANCED FUNCTIONAL MATERIALS
卷 31, 期 4, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202006824
关键词
hyperthermia; nanocrystals self-assemblies; photothermal therapy; tumor microenvironment
类别
资金
- Institut thematique multi-organismes (ITMO) Cancer
- doctoral school Frontieres du Vivant (FdV)-Programme Bettencourt
- Fondation ARC pour la recherche sur le cancer
- European Union [801305, 685795]
- IPGP multidisciplinary program PARI
- Paris-IdF region SESAME grant [12015908]
Fe(3)O(4) nanocrystals self-assemble into colloidosomes and supraballs, which exhibit different interactions within the tumor microenvironment compared to their individual building blocks. These hybrid self-assemblies target distinct compartments in the tumor microenvironment, leading to local photothermal damages that are not observed with isolated nanocrystals.
Fe(3)O(4)nanocrystals are self-assembled into two different conformations: colloidosome and supraball that confer them with distinct properties determining their photo-induced heating capacities. These self-assemblies are assessed for photothermal therapy, an adjuvant strategy for tumor therapy. The tumor microenvironment is a heterogeneous ecosystem including immune cells and the extracellular matrix. The interactions between photothermal therapy agents and the different components of the tumor microenvironment determine the outcome of this therapy. In this study, the fate of both colloidosomes and supraballs within the tumor microenvironment in comparison to their Fe(3)O(4)nanocrystal building blocks is revealed. This study highlights how these two hybrid self-assemblies target different compartments of the tumor microenvironment and trigger local photothermal damages that are inaccessible for isolated nanocrystals and not predicted by global temperature measurements.
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