Pathogenesis of necrotising enterocolitis: The impact of the altered gut microbiota and antibiotic exposure in preterm infants

Necrotising enterocolitis (NEC) is a devastating condition with high morbidity and mortality seen predominately in preterm infants. Multiple factors are associated with the pathogenesis of NEC. The widespread use of antibiotics in the neonatal intensive care unit might play a role in the pathogenesis of NEC in preterm infants. This review provides a summary on the intestinal microbiota in preterm infants with a focus on how antibiotic exposure may reduce the biodiversity of the intestinal microbiota and may predispose preterm infants to NEC. Conclusion Prolonged antibiotic therapy has been suggested as a risk factor for the development of NEC in preterm infants.

Automated summary

NEC is a devastating condition predominantly seen in preterm infants, with antibiotic exposure potentially reducing the biodiversity of intestinal microbiota and predisposing preterm infants to NEC. Prolonged antibiotic therapy has been suggested as a risk factor for the development of NEC in preterm infants.