4.2 Article

Brain-derived neurotrophic factor, depressive symptoms and somatic comorbidity in patients with coronary heart disease

期刊

ACTA NEUROPSYCHIATRICA
卷 33, 期 1, 页码 22-30

出版社

CAMBRIDGE UNIV PRESS
DOI: 10.1017/neu.2020.31

关键词

depression; BDNF; coronary heart disease; heart failure; somatic comorbidity; acute coronary syndrome

资金

  1. German Federal Ministry of Education and Research [01GY1154]

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The study found that while depressed patients with CHD tended to have lower BDNF concentrations, this association was not statistically significant. Reduced BDNF levels may be linked to congestive heart failure, but there was no significant correlation with acute coronary syndrome patients.
Objective: Depression and coronary heart disease (CHD) are highly comorbid conditions. Brain-derived neurotrophic factor (BDNF) plays an important role in cardiovascular processes. Depressed patients typically show decreased BDNF concentrations. We analysed the relationship between BDNF and depression in a sample of patients with CHD and additionally distinguished between cognitive-affective and somatic depression symptoms. We also investigated whether BDNF was associated with somatic comorbidity burden, acute coronary syndrome (ACS) or congestive heart failure (CHF). Methods: The following variables were assessed for 225 hospitalised patients with CHD: BDNF concentrations, depression [Patient Health Questionnaire-9 (PHQ-9)], somatic comorbidity (Charlson Comorbidity Index), CHF, ACS, platelet count, smoking status and antidepressant treatment. Results: Regression models revealed that BDNF was not associated with severity of depression. Although depressed patients (PHQ-9 score >7) had significantly lower BDNF concentrations compared to non-depressed patients (p = 0.04), this was not statistically significant after controlling for confounders (p = 0.15). Cognitive-affective symptoms and somatic comorbidity burden each closely missed a statistically significant association with BDNF concentrations (p = 0.08, p = 0.06, respectively). BDNF was reduced in patients with CHF (p = 0.02). There was no covariate-adjusted, significant association between BDNF and ACS. Conclusion: Serum BDNF concentrations are associated with cardiovascular dysfunction. Somatic comorbidities should be considered when investigating the relationship between depression and BDNF.

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