期刊
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
卷 52, 期 10, 页码 1148-1155出版社
OXFORD UNIV PRESS
DOI: 10.1093/abbs/gmaa102
关键词
NSCLC; anoikis resistance; microRNA-1827; caveolin-1; A549 cell
资金
- Project of Wuxi Municipal Science and Technology Bureau [CSE31N1621]
Anoikis resistance is a critical process for cancer cell metastasis in non-small cell lung cancer (NSCLC), and microRNA-1827 (miR-1827) is closely correlated with NSCLC metastasis. In this study, we aimed to evaluate the role of miR-1827 in regulating the anoikis resistance of NSCLC. The results showed that miR-1827 level was decreased in tumor tissues and cells and was correlated with tumor grade and lymph node (LN) metastasis. Overexpression of miR-1827 inhibited anchorage-independent growth and anoikis resistance in A549 cells. Bioinformatics and functional analysis identified that caveolin-1 (CAV-1) is directly targeted by miR-1827. Restoration of CAV-1 significantly attenuated miR-1827's effect on anoikis resistance in A549 cells. Our data identified a novel signaling axis of miR-1827/CAV-1 in regulating anoikis resistance, which might serve as a potential therapeutic target for metastatic NSCLC.
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