期刊
ACS NANO
卷 14, 期 10, 页码 13536-13547出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c05541
关键词
visualized tumor therapy; second near-infrared bioimaging; glutathione scavenging; theranostics; patient-derived xenograft model
类别
资金
- National Natural Science Foundation of China [81773642, 81701817, 51873218, 91859101]
- Natural Science Foundation of Guangdong Province [2019A1515011619]
- Guangdong Hong Kong Technology Cooperation Fund [2017A050506016]
- Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and technology, NSKF201819
- Natural Science Foundation of Beijing Province [2202071]
- Key Research and Development Plan of Hunan Province [2019SK2251]
- Ministry of Science and Technology of China [2018ZX10734401-018-006]
- China Postdoctoral Science Foundation [2019TQ0213]
- Shenzhen Science and Technology Project [JCYJ20180507183842516]
Killing tumor cells with a visualized system is a promising strategy in tumor therapy to achieve minimal side effects and high efficiency. Herein, a theranostic nanomedicine (AuNCs-Pt) is developed based on nanocarrier gold nanoclusters (AuNCs) with bifunctions of both NIR-I/NIR-II imaging and glutathione-scavenging abilities. AuNCs-Pt possesses NIR-II imaging capability on a fatal high-grade serous ovarian cancer (HGSOC) model in the deep abdomen, thus facilitating it to be a promising tool for monitoring platinum transportation. Meanwhile, AuNCs-Pt depletes intracellular glutathione to minimize platinum detoxification, effectively maximizing the chemotherapeutic efficacy of platinum. AuNCs-Pt is used to eradicate the tumor burden in this study on a HGSOC model and a patient-derived tumor xenograft model of hepatocellular carcinoma, suggesting great potential for clinical visualized therapy and platinum drug sensitization.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据