期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 42, 页码 47820-47830出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c12769
关键词
bioactive glass; superparamagnetic nanoparticles; sol-gel; coprecipitation; magnetic hyperthermia; bone regeneration; iron oxide
资金
- European Union as a part of the Fonds Europeen de Developpement Regional (FEDER)
- Conseil Regional Auvergne-Rhone-Alpes
- Materials Institute Carnot Alsace (project ProtRemote)
- Canceropole Est (project VIVIRMAG)
- French research programme Initiatives de Recherche Strategiques -projet Nan'eau (IDEX -Paris-Saclay and Ecole Polytechnique)
The past few decades have seen the development of new bone cancer therapies, triggered by the discovery of new biomaterials. When the tumoral area is small and accessible, the common clinical treatment implies the tumor mass removal followed by bone reconstruction or consolidation with a bioceramic or a metallic scaffold. Even though the treatment also involves chemotherapy or radiotherapy, resurgence of cancer cells remains possible. We have thus designed a new kind of heterostructured nanobiomaterial, composed of SiO2-CaO bioactive glass as the shell and superparamagnetic gamma-Fe2O3 iron oxide as the core in order to combine the benefits of bone repair thanks to the glass bioactivity and cancer cell destruction through magnetic hyperthermia. These multifunctional core-shell nanoparticles (NPs) have been obtained using a two-stage procedure, involving the coprecipitation of 11 nm sized iron oxide NPs followed by their encapsulation inside a bioactive glass shell by sol-gel chemistry. The as-produced spherical multicore-shell NPs show a narrow size distribution of 73 +/- 7 nm. Magnetothermal loss measurements by calorimetry under an alternating magnetic field and in vitro bioactivity assessment performed in simulated body fluid showed that these heterostructures exhibit a good heating capacity and a fast mineralization process (hydroxyapatite forming ability). In addition, their in vitro cytocompatibility, evaluated in the presence of human mesenchymal stem cells during 3 and 7 days, has been demonstrated. These first findings suggest that gamma-Fe2O3@SiO2-CaO heterostructures are a promising biomaterial to fill bone defects resulting from bone tumor resection, as they have the ability to both repair bone tissue and act as thermoseeds for cancer therapy.
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