期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 39, 页码 43341-43351出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c13504
关键词
liposome; drug delivery; oral administration; layer-by-layer assembly; intestinal absorption; surface modification
资金
- Shenzhen Science and Technology Innovation Committee [JCYJ20170818102436104]
- Natural Science Foundation of Guangdong Province [2018A030310485]
- Research Grants Council of the Government of Hong Kong Special Administrative Region [C5012-15E]
- Chinese University of Hong Kong, Shenzhen [PF01001421, UDF01001421]
Liposomes are small spherical vesicles composed mainly of phospholipids and cholesterol. Over the years, a number of liposomal formulations have shown clinical promise, but the use of liposomes in oral drug delivery is limited. This is partly due to the vulnerability of conventional liposomes to the detrimental effect of gastrointestinal destabilizing factors and also to the poor efficiency in intestinal absorption of liposomes. Some of these issues can be ameliorated using the layer-by-layer (LbL) assembly technology, which has been widely applied to modify the surface of various nanoparticulate systems. Discussions about LbL functionalization of liposomes as oral drug carriers, however, are scant in the literature. To fill this gap, this review presents an overview of the roles of LbL functionalization in the development of liposomes, followed by a discussion about major principles of molecular design and engineering of LbL-functionalized liposomes for oral drug delivery. Regarding the versatility offered by LbL assembly, it is anticipated that LbL-functionalized liposomes may emerge as one of the important carriers for oral drug administration in the future.
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