期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 43, 页码 48420-48431出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c16526
关键词
CuS; mesoporous silica nanoparticle; theranostic nanomedicine; tumor metastasis; photothermal therapy; immunotherapy
资金
- National Natural Science Foundation of China [81630047]
- Innovation Team Construction Project of Universities in Chongqing [CXTDG201602007]
Photothermal therapy (PTT) as a noninvasive and effective thermal therapeutic approach has attracted tremendously increasing interest because it can effectively eliminate the primary tumor and generate tumor-associated antigens, which could elicit antitumor immune responses. Herein, we report on the rational design and fabrication of copper sulfide (CuS)-based nanoplatform for cancer photothermal immunotherapy. The as-prepared core-shell CuS@mSiO(2)-PFP-PEG (CPPs) nanocomposites possess high biocompatibility, photoacoustic (PA)/ultrasound (US) imaging, and strong PTT effect upon 808 nm laser irradiation, indicating that the nanocomposites have a promising application in diagnosis and treatment of breast cancer with molecular classification. Importantly, we also elucidated that the CPP-triggered PTT in combination with anti-PD-1 checkpoint blockade therapy can not only obliterate primary tumor but also inhibit metastatic tumor in tumor-bearing mice. We believe that the CPPs have a good probability to serve as a useful nanoplatform for PTT, and this approach may provide a promising strategy for tumor-therapeutic modality with immunotherapy.
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