期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 38, 页码 42551-42557出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c12670
关键词
quinoxalinone; QCN; near-infrared (NIR) fluorescence; singlet oxygen; photodynamic therapy
资金
- Sanming Project of Medicine in Shenzhen [SZSM201801060]
- Joint Funds for the Innovation of Science and Technology, Fujian Province [2018Y9070]
- Middle-aged and Young Talents Training Program of Fujian Province Health Technology Project [2019-ZQN-71]
- Startup Fund for Scientific Research, Fujian Medical University [2017XQ1012]
- National Natural Science Foundation of China [81803438]
- Key Technology Research and Development Program of Shandong, China [2019GSF108043]
- Shanghai Jiao Tong University [A2018057]
Because light exhibits excellent spatiotemporal resolution, photodynamic therapy (PDT) is becoming a promising method for cancer treatment. However, in a single photosensitizer (PS), it remains a big challenge to achieve all key properties including effective singlet oxygen (O-1(2)) production under long-wavelength laser and bright near-infrared (NIR) emission without toxicity in the dark. In addition, clinically used traditional PSs encounter quenched fluorescence and decreased O-1(2) production because of molecular aggregation in aqueous solution. To solve the aforementioned issues, quinoxalinone CN (QCN) with effective O-1(2) generation under long-wavelength (530 nm) laser irradiation and aggregation-induced NIR emission is rationally designed by precise optimization of the quinoxalinone scaffold. After being encapsulated by an amphiphilic polymer (DSPE-PEG), the yielded nanoparticles exhibit highly efficient O-1(2) production and stable NIR fluorescence located at 800 nm without obvious toxicity under the dark. Both in vitro and in vivo evaluation identify that QCN would be a promising PS for image-guided PDT of tumors.
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