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B. Sosic-Jurjevic et al.
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Vineet Choudhary et al.
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W. Mike Henne et al.
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Lauren K. Fong et al.
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Nadja Kemmerling et al.
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Jochen Walter et al.
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Dieter Langosch et al.
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Vishal Agrawal et al.
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S. Kim et al.
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Ragna Sannerud et al.
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Stephen P. Duggan et al.
CELLULAR SIGNALLING (2016)
Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments
Xavier Meckler et al.
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Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2)
Konstantin Glebov et al.
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Marco Colonna et al.
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Bart De Strooper et al.
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Celeste M. Karch et al.
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Takuji Ohmoto et al.
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Yi-Lin Cheng et al.
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Mauricio G. Martin et al.
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Methodological considerations for the harmonization of non-cholesterol sterol bio-analysis
Dylan S. Mackay et al.
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Kristina Hofmann et al.
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γ-Secretase inhibitors and modulators
Todd E. Golde et al.
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A fast growing spectrum of biological functions of γ-secretase in development and disease
Nathalie Jurisch-Yaksi et al.
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Amyloid precursor protein controls cholesterol turnover needed for neuronal activity
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Min Suk Kang et al.
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Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage
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Christiane Reitz et al.
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Variant of TREM2 Associated with the Risk of Alzheimer's Disease
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CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance
Jennifer L. Cantley et al.
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Christoph Thiele et al.
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Upregulated function of mitochondria-associated ER membranes in Alzheimer disease
Estela Area-Gomez et al.
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Jihong Kang et al.
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Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease
Robin B. Chan et al.
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Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells
Katrijn Coen et al.
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Xulun Zhang et al.
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Paul J. Barrett et al.
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Rudolph E. Tanzi
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Hideki Hayashi
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Annakaisa Haapasalo et al.
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Dick Terwel et al.
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Weigang Cui et al.
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Frank W. Pfrieger et al.
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Maaike H. Oosterveer et al.
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Irfan Y. Tamboli et al.
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Imaging of lipid biosynthesis: how a neutral lipid enters lipid droplets
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Qiang Liu et al.
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Marcus O. W. Grimm et al.
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Natalie Landman et al.
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