期刊
LIFE-BASEL
卷 10, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/life10080150
关键词
protoenzyme; hyperbranched polymers; photocatalytic nanoparticles; polymer-supported nanoparticles; metal-sulfide nanocrystals
资金
- World Premier International Research Center Initiative (WPI), Ministry of Education, Culture, Sports, Science and Technology, Japan
- Japan Society for the Promotion of Science Kakenhi [17K01943, 18K14354]
- Tokyo Institute of Technology [1798]
- Grants-in-Aid for Scientific Research [18K14354, 17K01943] Funding Source: KAKEN
Enzymes are biological catalysts that are comprised of small-molecule, metal, or cluster catalysts augmented by biopolymeric scaffolds. It is conceivable that early in chemical evolution, ancestral enzymes opted for simpler, easier to assemble scaffolds. Herein, we describe such possible protoenzymes: hyperbranched polymer-scaffolded metal-sulfide nanocrystals. Hyperbranched polyethyleneimine (HyPEI) and glycerol citrate polymer-supported ZnS nanocrystals (NCs) are formed in a simple process. Transmission electron microscopy (TEM) analyses of HyPEI-supported NCs reveal spherical particles with an average size of 10 nm that undergo only a modest aggregation over a 14-day incubation. The polymer-supported ZnS NCs are shown to possess a high photocatalytic activity in an eosin B photodegradation assay, making them an attractive model for the study of the origin of life under the Zn world theory dominated by a photocatalytic proto-metabolic redox reaction network. The catalyst, however, could be easily adapted to apply broadly to different protoenzymatic systems.
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