相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。A Focused Chiral Mutant Library of the Amyloid β 42 Central Electrostatic Cluster as a Tool To Stabilize Aggregation Intermediates
Alejandro R. Foley et al.
JOURNAL OF ORGANIC CHEMISTRY (2020)
Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide
Thomas C. T. Michaels et al.
NATURE CHEMISTRY (2020)
Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-beta Oligomers
Ryan Limbocker et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Control of the toxic conformation of amyloid β42 by intramolecular disulfide bond formation
Yuka Matsushima et al.
CHEMICAL COMMUNICATIONS (2020)
Trapping and Characterization of Nontoxic Aβ42 Aggregation Intermediates
Alejandro R. Foley et al.
ACS CHEMICAL NEUROSCIENCE (2019)
Chirality Dependence of Amyloid Cellular Uptake and a New Mechanistic Perspective
Subrata Dutta et al.
CHEMBIOCHEM (2019)
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
Ryan Limbocker et al.
NATURE COMMUNICATIONS (2019)
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
Michele Perni et al.
ACS CHEMICAL BIOLOGY (2018)
Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions
Benedetta Mannini et al.
ACS CHEMICAL NEUROSCIENCE (2018)
Calcium signaling in Alzheimer's disease & therapies
Benjamin Chun-Kit Tong et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2018)
SAR by kinetics for drug discovery in protein misfolding diseases
Sean Chia et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease
Johnny Habchi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
Michele Perni et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
Giuliana Fusco et al.
SCIENCE (2017)
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
Francesco A. Aprile et al.
SCIENCE ADVANCES (2017)
Alzheimer's Disease and the Amyloid-β Peptide
M. Paul Murphy et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues
Ashley M. Smith et al.
NPJ REGENERATIVE MEDICINE (2017)
Suppression of Oligomer Formation and Formation of Non-Toxic Fibrils upon Addition of Mirror-Image Aβ42 to the Natural L-Enantiomer
Subrata Dutta et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
Effect of molecular chaperones on aberrant protein oligomers in vitro: super-versus sub-stoichiometric chaperone concentrations
Sara Cappelli et al.
BIOLOGICAL CHEMISTRY (2016)
Introduction of D-Glutamate at a Critical Residue of Aβ42 Stabilizes a Prefibrillary Aggregate with Enhanced Toxicity
Christopher J. A. Warner et al.
CHEMISTRY-A EUROPEAN JOURNAL (2016)
The amyloid hypothesis of Alzheimer's disease at 25years
Dennis J. Selkoe et al.
EMBO MOLECULAR MEDICINE (2016)
Amyloid-(1-42) Aggregation Initiates Its Cellular Uptake and Cytotoxicity
Sha Jin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein
Celine Galvagnion et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease
Johnny Habchi et al.
SCIENCE ADVANCES (2016)
Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity
Giuliana Fusco et al.
SCIENTIFIC REPORTS (2016)
Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases
Elisa Evangelisti et al.
SCIENTIFIC REPORTS (2016)
Influence of the β-Sheet Content on the Mechanical Properties of Aggregates during Amyloid Fibrillization
Francesco Simone Ruggeri et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Interactions between misfolded protein oligomers and membranes: A central topic in neurodegenerative diseases?
Maria Andreasen et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2015)
Nucleophosmin contains amyloidogenic regions that are able to form toxic aggregates under physiological conditions
Concetta Di Natale et al.
FASEB JOURNAL (2015)
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers
Samuel I. A. Cohen et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
Serene W. Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Anxious moments for the protein tyrosine phosphatase PTP1B
Navasona Krishnan et al.
TRENDS IN NEUROSCIENCES (2015)
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers
Samuel I. A. Cohen et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
Toxicity of Protein Oligomers Is Rationalized by a Function Combining Size and Surface Hydrophobicity
Benedetta Mannini et al.
ACS CHEMICAL BIOLOGY (2014)
Targeting the disordered C terminus of PTP1B with an allosteric inhibitor
Navasona Krishnan et al.
NATURE CHEMICAL BIOLOGY (2014)
The amyloid state and its association with protein misfolding diseases
Tuomas P. J. Knowles et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides
Georg Meisl et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation
Alexander K. Buell et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Chemical kinetics for drug discovery to combat protein aggregation diseases
Paolo Arosio et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2014)
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
Samuel I. A. Cohen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Protein Misfolded Oligomers: Experimental Approaches, Mechanism of Formation, and Structure-Toxicity Relationships
Francesco Bemporad et al.
CHEMISTRY & BIOLOGY (2012)
Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers
Elisa Evangelisti et al.
JOURNAL OF CELL SCIENCE (2012)
From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation
Samuel I. A. Cohen et al.
JOURNAL OF MOLECULAR BIOLOGY (2012)
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
Iryna Benilova et al.
NATURE NEUROSCIENCE (2012)
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers
Benedetta Mannini et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions
Heidi Olzscha et al.
CELL (2011)
Membrane surface charge dictates the structure and function of the epithelial Na+/H+ exchanger
Robert Todd Alexander et al.
EMBO JOURNAL (2011)
Sequestration of Toxic Oligomers by HspB1 as a Cytoprotective Mechanism
Juhi Ojha et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential
Michael Zasloff et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
ANS Binding Reveals Common Features of Cytotoxic Amyloid Species
Benedetta Bolognesi et al.
ACS CHEMICAL BIOLOGY (2010)
Amyloid beta-Protein Aggregation Produces Highly Reproducible Kinetic Data and Occurs by a Two-Phase Process
Erik Hellstrand et al.
ACS CHEMICAL NEUROSCIENCE (2010)
Resveratrol Selectively Remodels Soluble Oligomers and Fibrils of Amyloid Aβ into Off-pathway Conformers
Ali Reza A. Ladiwala et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
A causative link between the structure of aberrant protein oligomers and their toxicity
Silvia Campioni et al.
NATURE CHEMICAL BIOLOGY (2010)
Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia
Cindy M. Sondag et al.
JOURNAL OF NEUROINFLAMMATION (2009)
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
Dagmar E. Ehrnhoefer et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Membrane phosphatidylserine regulates surface charge and protein localization
Tony Yeung et al.
SCIENCE (2008)
Wavelength shifts in solid-state circular dichroism spectra: A possible explanation
Ettore Castiglioni et al.
CHIRALITY (2007)
Soluble protein oligomers in neurodegeneration:: lessons from the Alzheimer's amyloid β-peptide
Christian Haass et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Molecular anatomy of a trafficking organelle
Shigeo Takamori et al.
CELL (2006)
Unfolding the role of protein misfolding in neurodegenerative diseases
C Soto
NATURE REVIEWS NEUROSCIENCE (2003)
Appetite suppression and weight reduction by a centrally active aminosterol
RS Ahima et al.
DIABETES (2002)
Antimicrobial peptides of multicellular organisms
M Zasloff
NATURE (2002)
分享论文
