The bidirectional relationship between CFTR and lipids

In this review, Cottrill et al. discuss how the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) interacts with the membrane into which it is inserted. They summarize recent insight into the ways lipids are imbalanced in CF epithelia and how the lipid environment affects CFTR. Cystic Fibrosis (CF) is the most common life-shortening genetic disease among Caucasians, resulting from mutations in the gene encoding the Cystic Fibrosis Transmembrane conductance Regulator (CFTR). While work to understand this protein has resulted in new treatment strategies, it is important to emphasize that CFTR exists within a complex lipid bilayer - a concept largely overlooked when performing structural and functional studies. In this review we discuss cellular lipid imbalances in CF, mechanisms by which lipids affect membrane protein activity, and the specific impact of detergents and lipids on CFTR function.