期刊
PHARMACEUTICALS
卷 13, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ph13060123
关键词
Plectranthussp; cytotoxic activity; apoptosis; DNA damage; mitochondrial membrane potential; ROS levels; gene expression
资金
- Fundacao para a Ciencia e a Tecnologia (FCT), Portugal [UIDB/04567/2020, UIDP/04567/2020, CBIOS/PRUID/BI1/2017, SFRH/BD/137671/2018]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/137671/2018] Funding Source: FCT
Plectranthusspp. is widely known for its medicinal properties and bioactive metabolites. The cytotoxic and genotoxic properties of the four known abietane diterpenoids: 7 alpha-Acetoxy-6 beta-hydroxyroyleanone (Roy), 6,7-dehydroroyleanone (Deroy), 7 beta,6 beta-dihydroxyroyleanone6 (Diroy), and Parvifloron D (Parv), isolated fromP. madagascariensis(Roy, DeRoy, and Diroy) andP. ecklonii(Parv) were evaluated. The tested compounds showed cytotoxic effects against the human leukemia cell line CCRF-CEM and the lung adenocarcinoma cell line A549. All tested compounds induced apoptosis by altering the level of pro- and anti-apoptotic genes. The results show that from the tested diterpenoids, Roy and Parv demonstrated the strongest activity in both human cancer cell lines, changing the permeability mitochondrial membrane potential and reactive oxygen species (ROS) levels, and possibly inducing mtDNA or nDNA damage. In conclusion, the abietane diterpenoids tested may be used in the future as potential natural chemotherapeutic agents.
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