期刊
ISCIENCE
卷 23, 期 8, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.isci.2020.101368
关键词
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资金
- Wellcome Trust Investigator Award [100/974/C/13/Z]
- BBSRC Norwich Research Park Bioscience Doctoral Training grant [BB/M011216/1]
- Institute Strategic Programme Gut Microbes and Health [BB/R012490/1, BBS/E/F/000PR10353, BBS/E/F/000PR10356]
- Institute Strategic Programme Gut Health and Food Safety [BB/J004529/1]
- Medical Research Council Intermediate Research Fellowship in Data Science (UK MED-BIO) [MR/L01632X/1]
- Research Council of Norway (FRIPRO program) [250479]
- European Research Commission Starting Grant Fellowship [336355 -MicroDE]
- BBSRC [BBS/E/F/00044409, BBS/E/F/000PR10353, BBS/E/F/000PR10356, 1786430] Funding Source: UKRI
- MRC [MR/L01632X/1] Funding Source: UKRI
Diet-microbe interactions play a crucial role in modulation of the early life micro-biota and infant health. Bifidobacterium dominates the breast-fed infant gut and may persist in individuals during transition from a milk-based to a more diversified diet. Here, we investigated adaptation of Bifidobacterium longum to the changing nutritional environment. Genomic characterization of 75 strains isolated from nine either exclusively breast-or formula-fed (pre-weaning) infants in their first 18 months revealed subspecies-and strain-specific intra-individual genomic diversity with respect to carbohydrate metabolism, which corresponded to different dietary stages. Complementary phenotypic studies indicated strain-specific differences in utilization of human milk oligosaccharides and plant carbohydrates, whereas proteomic profiling identified gene clusters involved in metabolism of selected carbohydrates. Our results indicate a strong link between infant diet and B. longum diversity and provide additional insights into possible competitive advantage mechanisms of this Bifidobacterium species and its persistence in a single host.
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