期刊
BLOOD ADVANCES
卷 4, 期 15, 页码 3795-3803出版社
ELSEVIER
DOI: 10.1182/bloodadvances.2020002127
关键词
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类别
资金
- Human Frontier Science Program long-term fellowship
- Swiss National Science Foundation postdoctoral mobility fellowship
- Harvard Stem Cell Institute
- National Institutes of Health, National Cancer Institute [CA194596, CA193461]
- Gerald and Darlene Jordan Professor of Medicine Chair
The bone marrow is a complex tissue in which heterogeneous populations of stromal cells interact with hematopoietic cells to dynamically respond to organismal needs in defense, hemostasis, and oxygen delivery. Physiologic challenges modify stromal/hematopoietic cell interactions to generate changes in blood cell production. When either stroma or hematopoietic cells are impaired, the system distorts. The distortions associated with myeloid malignancy are reviewed here and may provide opportunities for therapeutic intervention.
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