期刊
BRAIN SCIENCES
卷 10, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/brainsci10070469
关键词
minimally conscious state; neuromodulation; non-invasive brain stimulation; electrophysiology; brain injury
资金
- University and University Hospital of Liege
- Belgian National Funds for Scientific Research (FRS-FNRS)
- European Union's Horizon 2020 Framework Programme for Research and Innovation (Human Brain Project SGA2) [785907]
- European Union's Horizon 2020 Framework Programme for Research and Innovation (Human Brain Project SGA3)
- Luminous project [EU-H2020-fetopen-ga686764]
- European Space Agency (ESA)
- Belgian Federal Science Policy Office (BELSPO)
- BIAL Foundation
- AstraZeneca Foundation
- King Baudouin Foundation
- Fund Generet
- Marie Sklodowska-Curie Actions [H2020-MSCA-IF-2016-ADOC-752686]
- French Speaking Community Concerted Research Action [ARC 12-17/01]
- James McDonnell Foundation
- Mind Science Foundation
- IAP research network of the Belgian Government (Belgian Science Policy) [P7/06]
- European Commission
- Public Utility Foundation 'Universite Europeenne du Travail'
- Fondazione Europea di Ricerca Biomedica
- DOCMA project [EU-H2020-MSCA-RISE-778234]
Background.Transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (lDLPFC) was reported to promote the recovery of signs of consciousness in some patients in a minimally conscious state (MCS), but its electrophysiological effects on brain activity remain poorly understood.Objective.We aimed to assess behavioral (using the Coma Recovery Scale-Revised; CRS-R) and neurophysiological effects (using high density electroencephalography; hdEEG) of lDLPFC-tDCS in patients with prolonged disorders of consciousness (DOC).Methods.In a double-blind, sham-controlled, crossover design, one active and one sham tDCS (2 mA, 20 min) were delivered in a randomized order. Directly before and after tDCS, 10 min of hdEEG were recorded and the CRS-R was administered.Results.Thirteen patients with severe brain injury were enrolled in the study. We found higher relative power at the group level after the active tDCS session in the alpha band in central regions and in the theta band over the frontal and posterior regions (uncorrected results). Higher weighted symbolic mutual information (wSMI) connectivity was found between left and right parietal regions, and higher fronto-parietal weighted phase lag index (wPLI) connectivity was found, both in the alpha band (uncorrected results). At the group level, no significant treatment effect was observed. Three patients showed behavioral improvement after the active session and one patient improved after the sham.Conclusion.We provide preliminary indications that neurophysiological changes can be observed after a single session of tDCS in patients with prolonged DOC, although they are not necessarily paralleled with significant behavioral improvements.
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