期刊
ANNALS OF TRANSLATIONAL MEDICINE
卷 8, 期 14, 页码 -出版社
AME PUBL CO
DOI: 10.21037/atm.2020.02.157
关键词
Invadopodia; metalloproteases; serine protease; lipid raft; cancer invasion; metastasis
资金
- National Science Centre [2017/25/B/NZ5/01251]
The invasive nature of many cancer cells involves the formation of F-actin-based, lipid-raft -enriched membrane protrusions known as invadopodia or, more broadly, invadosomes. Invadopodia are specialized adhesive structures arising from ventral cell surface within cell-extracellular matrix (ECM) contacts and concentrate high proteolytic activities that allow cells to overcome the dense scaffold of local microenvironment, comprising a natural barrier to cell spreading. This degradative activity distinguishes invadopodia from other adhesive structures like focal adhesions, lamellipodia or filopodia, and is believed to drive cancer progression.
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