期刊
EVOLUTION MEDICINE AND PUBLIC HEALTH
卷 -, 期 1, 页码 109-113出版社
OXFORD UNIV PRESS
DOI: 10.1093/emph/eoaa021
关键词
coronavirus; COVID-19; SARS-CoV-2; molecular evolution; ACE2; host; pathogen
资金
- Natural Science and Engineering Research Council of Canada (NSERC) [RGPIN-04034]
- Killam Pre-Doctoral Award
- Nova Scotia Graduate Scholarship
- Dalhousie University's Presidents Award
SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2) has been reported to infect domesticated animals in a species-specific manner, where cats were susceptible but not dogs. Using the recently published crystal structure of the SARS-CoV-2 spike protein complexed with the human host cell receptor angiotensin converting enzyme 2 (ACE2), we characterized the structure and evolution of ACE2 in several of these species and identify a single interacting amino acid residue conserved between human and Felidae ACE2 but not in Canidae that correlates with virus susceptibility. Using computational analyses we describe how this site likely affects ACE2 targeting by the virus. Thus, we highlight how evolution-based approaches can be used to form hypotheses and study animal transmission of such viruses in the future.
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