期刊
JOURNAL OF PHARMACEUTICAL ANALYSIS
卷 10, 期 5, 页码 426-433出版社
ELSEVIER
DOI: 10.1016/j.jpha.2020.05.013
关键词
Fluorescence imaging; Drug target; Chemical probe; Ligand-directed chemistry
资金
- Japan Science and Technology Agency (JST) ERATO Grant [JPMJER1802]
- [17H06348]
Fluorescence imaging can provide valuable information on the expression, distribution, and activity of drug target proteins. Chemical probes are useful small-molecule tools for fluorescence imaging with high structural flexibility and biocompatibility. In this review, we briefly introduce two classes of fluorescent probes for the visualization of drug target proteins. Enzymatically activatable probes make use of the specific enzymatic transformations that generally produce a fluorogenic response upon reacting with target enzymes. Alternatively, specific imaging can be conferred with a ligand that drives the probes to target proteins, where the labeling relies on noncovalent binding, covalent inhibition, or traceless labeling by ligand-directed chemistry. (C) 2020 Xi'an Jiaotong University. Production and hosting by Elsevier B.V.
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