期刊
ANTIOXIDANTS
卷 9, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/antiox9080703
关键词
antioxidant enzymes; oxidative stress; reactive oxygen species; hyperthermophiles; archaea
资金
- Fondo per il Finanziamento delleAttivita' Base di Ricerca (FFABR 2017) Ministero dell'Universita e della Ricerca (MIUR) Italy
- ERANETCofund MarTERA
To fight reactive oxygen species (ROS) produced by both the metabolism and strongly oxidative habitats, hyperthermophilic archaea are equipped with an array of antioxidant enzymes whose role is to protect the biological macromolecules from oxidative damage. The most common ROS, such as superoxide radical (O-2(center dot-)) and hydrogen peroxide (H2O2), are scavenged by superoxide dismutase, peroxiredoxins, and catalase. These enzymes, together with thioredoxin, protein disulfide oxidoreductase, and thioredoxin reductase, which are involved in redox homeostasis, represent the core of the antioxidant system. In this review, we offer a panorama of progression of knowledge on the antioxidative system in aerobic or microaerobic (hyper)thermophilic archaea and possible industrial applications of these enzymes.
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