期刊
ANTIOXIDANTS
卷 9, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/antiox9080646
关键词
Antitumoral; betalains; C; elegans; phytochemical; chemotherapy; tryptophan-betaxanthin
资金
- Spanish Ministry of Science and Innovation (MCI/AEI/FEDER, UE) [AGL2017-86526-P]
- Programa de Ayudas a Grupos de Excelencia de la Region de Murcia, Fundacion Seneca, Agencia de Ciencia y Tecnologia de la Region de Murcia (Spain) [19893/GERM/15]
- MEC-FSE (Spain)
- Fundacion Seneca (Spain)
- University of Murcia, Spain
Betalains are plants pigments identified as potent antioxidant molecules, naturally present in foods like beetroot and prickly pears. Although activities described for betalain-containing formulations include cancer prevention and treatment, the use of extracts instead of purified pigments has avoided the investigation of the real chemopreventive and chemotherapeutic potential of these phytochemicals. Three betalain-rich extracts and six individual pure betalains were used in this work to characterize the activity and to explore possible molecular mechanisms. The animal modelCaenorhabditis elegans(tumoral strain JK1466) was used to evaluate the effect of betalains as chemotherapeutics drugs. An objective evaluation method of tumor growth inC. eleganshas been developed to assess the possible antitumoral activity of the different treatments. This protocol allowed a fast and reliable screening of possible antitumoral drugs. Among the betalains tested, tryptophan-betaxanthin reduced tumor size by 56.4% and prolonged the animal's lifespan by 9.3%, indicating high effectiveness and low toxicity. Structure-activity relationships are considered. Assays with mutant strains ofC. elegansshowed that the mechanism underlying these effects was the modulation of the DAF-16 transcription factor and the insulin signaling pathway. Our results indicate that tryptophan-betaxanthin and related betalains are strong candidates as antitumoral molecules in cancer treatment.
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