期刊
ANTIOXIDANTS
卷 9, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/antiox9070640
关键词
cardiac fibrosis; insulin resistance; microbiota; mucins; obesity
资金
- Instituto de Salud Carlos III-Fondo Europeo de Desarrollo Regional (FEDER) a way to build Europe, Ministerio de Economia y Competitividad [PI18/00257, SAF2016-81063]
- CAM (Atraccion de talento)
- FPI Program from the Government of Castilla y Leon (FSE)
Background: The objective of this study is to determine the role of mitochondrial oxidative stress in the dysbiosis associated with a high fat diet in rats. In addition, the impact of gut microbiota (GM) in the cardiometabolic consequences of diet-induced obesity in rats has been evaluated. Methods: Male Wistar rats were fed either a high fat diet (HFD) or a control (CT) one for 6 weeks. At the third week, one-half of the animals of each group were treated with the mitochondrial antioxidant MitoTempo (MT; 0.7 mgKg(-1)day(-1)i.p). Results: Animals fed an HFD showed a lower microbiota evenness and diversity in comparison to CT rats. This dysbiosis is characterized by a decrease inFirmicutes/Bacteroidetesratio and relevant changes at family and genera compared with the CT group. This was accompanied by a reduction in colonic mucin-secreting goblet cells. These changes were reversed by MT treatment. The abundance of certain genera could also be relevant in the metabolic consequences of obesity, as well as in the occurrence of cardiac fibrosis associated with obesity. Conclusions: These results support an interaction between GM and mitochondrial oxidative stress and its relation with development of cardiac fibrosis, suggesting new approaches in the management of obesity-related cardiometabolic consequences.
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