期刊
BIOMOLECULES
卷 10, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/biom10071017
关键词
IL-10; neurodegeneration; neuroinflammation; microglia; signaling
资金
- Fondo per i Progetti di Ricerca di Ateneo (anno 2018), University of Foggia, Italy
- Fondo di Ateneo (2015), University of Bari, Italy
IL-10, an immunosuppressive cytokine, is considered an important anti-inflammatory modulator of glial activation, preventing inflammation-mediated neuronal degeneration under pathological conditions. In this narrative review, we summarize recent insights about the role of IL-10 in the neurodegeneration associated with neuroinflammation, in diseases such as Multiple Sclerosis, Traumatic Brain Injury, Amyotrophic lateral sclerosis, Alzheimer's Disease, and Parkinson's Disease, focusing on the contribution of this cytokine not only in terms of protective action, but also as possibly responsible for clinical worsening. The knowledge of this double face of the same coin, regarding the biological role of the IL-10, could aid the development of targeted therapies useful for limiting neurodegenerative processes.
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