期刊
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2020.00830
关键词
enzyme-polymer hybrids; enzyme immobilization; polymeric supports; biocatalysis; nanocarriers; stabilization of enzymes
资金
- Spanish Ministry of Economy and Competitiveness (MINECO)
- FEDER funds in the frame of Plan Nacional -Retos para la Sociedad [MAT2017-88808-R, PID2019-110239RB-I00]
- Maria de Maeztu Units of Excellence Programme [MDM-2016-0618]
- Spanish Research Agency (AEI) [RYC2018-025923-I]
- Basque Government [PRE_2019_2_0147]
The number of methodologies for the immobilization of enzymes using polymeric supports is continuously growing due to the developments in the fields of biotechnology, polymer chemistry, and nanotechnology in the last years. Despite being excellent catalysts, enzymes are very sensitive molecules and can undergo denaturation beyond their natural environment. For overcoming this issue, polymer chemistry offers a wealth of opportunities for the successful combination of enzymes with versatile natural or synthetic polymers. The fabrication of functional, stable, and robust biocatalytic hybrid materials (nanoparticles, capsules, hydrogels, or films) has been proven advantageous for several applications such as biomedicine, organic synthesis, biosensing, and bioremediation. In this review, supported with recent examples of enzyme-protein hybrids, we provide an overview of the methods used to combine both macromolecules, as well as the future directions and the main challenges that are currently being tackled in this field.
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