期刊
SCIENCE IMMUNOLOGY
卷 5, 期 49, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciimmunol.abd7114
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资金
- University of Pennsylvania Institute for Immunology Glick COVID-19 research award
- NIH [HL137006, HL137915, T32 CA009140, UM1-AI144288, P30-CA016520, AI105343, AI115712, AI117950, AI108545, AI082630, CA210944]
- Mentored Clinical Scientist Career Development Award from the National Institute of Allergy and Infectious Diseases [K08 AI136660]
- Athersys Inc.
- Biomarck Inc.
- Marcus Foundation for Research
- Parker Institute for Cancer Immunotherapy
- [R01 AI118694]
- [UC4 DK112217]
Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2-infected and -recovered individuals. We identified extensive induction and activation of multiple immune lineages, including T cell activation, oligoclonal plasmablast expansion, and Fc and trafficking receptor modulation on innate lymphocytes and granulocytes, that distinguished severe COVID-19 cases from healthy donors or SARS-CoV-2-recovered or moderate severity patients. We found the neutrophil-to-lymphocyte ratio to be a prognostic biomarker of disease severity and organ failure. Our findings demonstrate broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARSCoV-2 infection and warrant therapeutic investigation.
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