期刊
RESEARCH
卷 2020, 期 -, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.34133/2020/2424972
关键词
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资金
- Spanish MINECO [CTQ2015-68879-R, CTQ2015-72471-EXP, RTI2018-098164-B-I00]
- MINECO [SEV-2014-0425, PRE2018-083712, FJCI-2015-25578]
- European Union's Horizon 2020 research and innovation program, under the Marie SklodowskaCurie Individual Fellowship (H2020-MSCA-IF-2018, DNA-bots)
- la Caixa Foundation through IBEC International PhD Programme la Caixa Severo Ochoa fellowships [LCF/BQ/SO16/52270018]
- European Research Council program under grant ERC-CoG Qnano-MECA [64790]
- Fundacio Privada Cellex
- CERCA program
- Spanish Ministry of Economy and Competitiveness [FIS2016-80293-R]
- Severo Ochoa Program for Centres of Excellence in RD [SEV-2015-0522]
Enzyme-powered motors self-propel through the catalysis of in situ bioavailable fuels, which makes them excellent candidates for biomedical applications. However, fundamental issues like their motion in biological fluids and the understanding of the propulsion mechanism are critical aspects to be tackled before a future application in biomedicine. Herein, we investigated the physicochemical effects of ionic species on the self-propulsion of urease-powered micromotors. Results showed that the presence of PBS, NaOH, NaCl, and HEPES reduced self-propulsion of urease-powered micromotors pointing towards ion-dependent mechanisms of motion. We studied the 3D motion of urease micromotors using digital holographic microscopy to rule out any motor-surface interaction as the cause of motion decay when salts are present in the media. In order to protect and minimize the negative effect of ionic species on micromotors' performance, we coated the motors with methoxypolyethylene glycol amine (mPEG) showing higher speed compared to noncoated motors at intermediate ionic concentrations. These results provide new insights into the mechanism of urease-powered micromotors, study the effect of ionic media, and contribute with potential solutions to mitigate the reduction of mobility of enzyme-powered micromotors.
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