期刊
NATURE REVIEWS CHEMISTRY
卷 4, 期 7, 页码 334-346出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41570-020-0191-2
关键词
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资金
- National Institutes of Health [R35 GM124880, T32 GM008353]
Enzymes exercise impeccable control over chemoselectivity, site selectivity and stereoselectivity in reactions they mediate, such that we have witnessed a surge in the development of new biocatalytic methods. Although carbon-carbon (C-C) bonds are the central framework of organic molecules, biocatalytic methods for their formation have largely been limited to a select few lyase enzymes. Thus, despite several decades of research, there are not many biocatalytic C-C-bond-forming transformations at our disposal. This Review describes the suite of enzymes available for highly selective, biocatalytic C-C bond formation. We discuss each class of enzyme in terms of native activity, alteration of this activity through protein or substrate engineering, and its utility in abiotic synthesis.
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