期刊
FOOD SCIENCE & NUTRITION
卷 8, 期 8, 页码 4370-4378出版社
WILEY
DOI: 10.1002/fsn3.1734
关键词
fermentation; jackfruit leaves; jackfruit pulp; Sprague-Dawley rats; toxicity
资金
- Malaysia Government Development Fund [RMK-11, P21003004050001]
Fermented jackfruit (Artocarpus heterophyllus) extracts were produced using pure symbiotic culture of bacteria and yeast (SCOBY) under controlled fermentation process. Both female and male Sprague-Dawley rats were orally administrated with 4,000 mg/kg of fermented jackfruit pulp and leaves extracts for 28 consecutive days. Body weight of rats was recorded at 1-week interval until necropsy day. There was no mortality reported along the experiment with no significant differences (p > .05) record among organ histopathology and blood biochemical parameters in treated groups when compared to control group. Interestingly, there were significant differences (p < .05) in the lower body weight gained of treated rats groups as opposed to control group, indicating the potential anti-obesity effect of fermented jackfruit extracts. In conclusion, no toxicity symptoms were observed in 28 days oral administration toxicity study of fermented jackfruit pulp and leaves extracts in Sprague-Dawley rats for both sexes.
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